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Updated: Jun 1, 2026
09:27
Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles
Published on: August 16, 2012
[Pelletization of melts and liquids]
1Veterinární a farmaceutická univerzita Brno, Farmaceutická fakulta, Ustav technologie léků. rabiskovam@vfu.cz
Summary
New pelletization techniques prepare solid dosage forms from melts and liquids, advancing pharmaceutical manufacturing. These methods, including hot melt extrusion and cryopelletization, offer innovative approaches to drug delivery systems.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
- Materials Science
Context:
- Traditional wetting-based pelletization methods have been industrial standards for decades.
- Existing technologies include coating pans, fluid-bed equipment, and extrusion/spheronization.
- Recent advancements focus on novel pellet preparation from melts and liquids.
Purpose:
- To review and present emerging pelletization methods utilizing melts and liquids.
- To highlight the principles behind fluid hot melt agglomeration, hot melt extrusion, freeze pelletization, jet cutting, and cryopelletization.
- To discuss the significance of these new techniques in pharmaceutical manufacturing.
Summary:
- This article explores advanced pelletization techniques for creating solid dosage forms.
- Methods discussed include fluid hot melt agglomeration, hot melt extrusion, and freeze pelletization for melt-based preparations.
- Jet cutting and cryopelletization are detailed for liquid-based pellet preparation.
Impact:
- These novel methods expand the toolkit for pharmaceutical manufacturers.
- Potential for improved drug formulation and delivery through innovative pellet designs.
- Contributes to the evolution of solid dosage form production technologies.
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