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Updated: Jun 1, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
A nonpeptidic reverse-turn scaffold stabilized by urea-based dual intramolecular hydrogen bonding
Amiya K Medda1, Chul Min Park, Aram Jeon
1Molecular-Level Interface Research Center, Department of Chemistry, KAIST, Daejeon 305-701, Korea.
Abstract:
A novel nonpeptidic reverse-turn scaffold containing urea fragments that are connected by a conformationally constrained D-prolyl-cis-1,2-diaminocyclohexane (D-Pro-DACH) linker is reported. The scaffold adopts a well-defined reverse-turn conformation that is stabilized by dual intramolecular hydrogen bonding in both solution and solid states.
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