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Cutaneous malakoplakia simulating relapsing malignant lymphoma.

J P Palazzo1, D J Ellison, I E Garcia

  • 1Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111.

Journal of Cutaneous Pathology
|June 1, 1990
PubMed
Summary
This summary is machine-generated.

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This case report details a rare instance of cutaneous malakoplakia in a patient with diffuse large non-cleaved cell lymphoma. The condition presented unusually on the skin, despite systemic immunosuppression.

Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Malignant lymphoma, diffuse large non-cleaved cell type, can present with widespread lymph node involvement.
  • Cutaneous malakoplakia is a rare condition typically affecting the urinary tract or gastrointestinal tract.

Observation:

  • A 42-year-old male with lymphoma developed a non-regressing left groin mass, initially suspected as recurrent lymphoma.
  • Skin biopsy revealed an ulcer and abscess with foamy histiocytes containing Michaelis-Gutmann bodies, characteristic of malakoplakia.
  • Monocyte cultures exhibited ultrastructural features mirroring tissue findings, suggesting systemic monocyte-macrophage lineage involvement.

Findings:

  • The patient presented with cutaneous malakoplakia in the left groin, an atypical site for this condition.

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  • Microscopic examination confirmed Michaelis-Gutmann bodies, indicative of malakoplakia, within a skin ulcer and abscess.
  • Systemic involvement of the monocyte macrophage lineage was suggested by cultured peripheral blood monocytes.

    • Implications:

    • This case highlights an unusual presentation of cutaneous malakoplakia in an immunocompromised lymphoma patient.
    • The findings suggest a potential link between immunosuppression, lymphoma, and atypical malakoplakia development.
    • Further research may elucidate the pathogenesis of malakoplakia in immunocompromised individuals.