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Updated: Jun 1, 2026

Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution
Published on: July 4, 2014
Analysis of counterfeit pharmaceutical tablet cores utilizing macroscopic infrared spectroscopy and infrared
Adam Lanzarotta1, Kendra Lakes, Curtis A Marcott
1Trace Examination Section, FDA Forensic Chemistry Center, Cincinnati, Ohio 45237, United States. adam.lanzarotta@fda.hhs.gov
Abstract:
Advantages and limitations of analyzing authentic and counterfeit pharmaceutical tablets with both macro (nonimaging) attenuated total internal reflection Fourier transform infrared (ATR-FT-IR) spectroscopy and micro ATR-FT-IR spectroscopic imaging have been evaluated. The results of this study demonstrated that micro ATR imaging was more effective for extracting formulation information (sourcing), whereas a macro ATR approach was better suited for counterfeit detection (screening). More importantly, this study demonstrated that a thorough analysis of the counterfeit core can be achieved by combining the results of both techniques.
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