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Updated: Jun 1, 2026
Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
Published on: February 16, 2022
Nitric oxide and adverse events of vascular endothelial growth factor inhibitors
1Department of Haematology, University of Liverpool, Liverpool, UK. jeckothachil@yahoo.co.uk
Background:
Angiogenesis inhibitors targeting the vascular endothelial growth factor (VEGF) signalling pathways have demonstrated therapeutic efficacy in a wide variety of malignancies. With their increased use, adverse events, some common and certain rare but characteristic complications, are being recognized. The exact mechanisms for the development of at least some of these side effects are not entirely clear.
Scope:
Review of the current literature with respect to mechanisms for the development of side effects to VEGF blocking agents was reviewed.
Findings:
Nitric oxide is a key molecule in the downstream signalling pathway for VEGF. Blockade of nitric oxide by the VEGF antagonists results in several class-specific adverse events.
Conclusion:
Nitric oxide can be considered as an important factor in the development of most of the common and rare adverse events related to VEGF antagonists.
Insights
Vascular Endothelial Growth Factor (VEGF) antagonists can cause side effects. Nitric oxide blockade is a key mechanism driving these adverse events, impacting both common and rare complications.
Area of Science:
- Oncology
- Molecular Biology
- Pharmacology
Background:
- Angiogenesis inhibitors targeting VEGF pathways are effective cancer treatments.
- Adverse events associated with VEGF inhibitors are increasingly recognized.
- Mechanisms underlying VEGF inhibitor side effects require further elucidation.
Purpose of the Study:
- To review the literature on mechanisms causing side effects of VEGF blocking agents.
- To identify the role of nitric oxide in VEGF inhibitor-induced adverse events.
Main Methods:
- Literature review of current research on VEGF antagonist side effect mechanisms.
Main Results:
- Nitric oxide is crucial in the downstream signaling of VEGF.
- VEGF antagonists block nitric oxide, leading to class-specific adverse events.
- Nitric oxide blockade contributes to common and rare side effects.
Conclusions:
- Nitric oxide plays a significant role in adverse events associated with VEGF antagonists.
- Understanding nitric oxide's role can inform management of VEGF inhibitor toxicities.
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