Protein kinase homology models: recent developments and results
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Updated: Jun 1, 2026

Identification of Kinase-substrate Pairs Using High Throughput Screening
Published on: August 29, 2015
T Tuccinardi1, Adriano Martinelli
1Dipartimento di Scienze Farmaceutiche, Università di Pisa, via Bonanno 6, 56126 Pisa, Italy. tuccinardi@farm.unipi.it
Abstract:
Protein kinases are key regulators of cell function that constitute one of the largest and most functionally diverse gene families, and knowledge of their three-dimensional structure could be of great help in the rational design of specific ligands. However, only about one quarter of human protein kinase structures has been experimentally defined; thus, kinase homology modeling techniques have been widely diffused. In this review, the most recent kinase homology models are reported, together with the most recent approaches and the main validation methods.
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