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Related Experiment Videos

Prochlorperazine in childhood: side-effects.

D J Lankamp, J Willemse, S A Pikaar

    Clinical Neurology and Neurosurgery
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

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    Prochlorperazine causes neurological side-effects in children, primarily dyskinesia, regardless of dose. These effects resolve spontaneously or with orphenadrine treatment.

    Area of Science:

    • Pediatric Neurology
    • Clinical Pharmacology

    Background:

    • Prochlorperazine is a commonly prescribed antiemetic and antipsychotic medication.
    • Neurological side-effects, particularly in children, require careful monitoring.

    Purpose of the Study:

    • To investigate and document the side-effects of prochlorperazine in pediatric patients.
    • To compare observed side-effects with existing literature data.

    Main Methods:

    • A cohort of thirty-six children under sixteen years of age receiving prochlorperazine was monitored.
    • Observed side-effects were systematically recorded and compared to published data.

    Main Results:

    • Predominantly neurological side-effects were observed, independent of dosage.

    Related Experiment Videos

  • Key manifestations included impaired consciousness, dyskinesia, pyramidal signs, and hypertonus.
  • Dyskinesia was identified as the most frequent neurological sign.

    • Conclusions:

    • Prochlorperazine can induce significant neurological side-effects in children.
    • These adverse events are reversible upon drug discontinuation and treatable with orphenadrine.