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Related Experiment Videos

Dithiocarbamate therapy for nickel dermatitis.

D Spruit, P J Bongaarts, G J de Jongh

    Contact Dermatitis
    |December 1, 1978
    PubMed
    Summary

    Diethyldithiocarbamate (DDC) increased nickel excretion in urine tenfold but did not improve nickel contact dermatitis symptoms. Further research is needed to confirm DDC

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    Area of Science:

    • Dermatology
    • Toxicology
    • Internal Medicine

    Background:

    • Nickel contact dermatitis can be exacerbated by internal nickel exposure.
    • Diethyldithiocarbamate (DDC) chelates nickel ions, potentially inactivating them.

    Observation:

    • A patient received approximately 1 g/day of DDC orally.
    • Nickel excretion in urine increased significantly (about tenfold).
    • Nickel elimination in scalp hair showed no increase.

    Findings:

    • A daily dose of 1.2 g DDC for 2 months resulted in a slightly negative nickel balance.
    • Organ nickel content was not significantly depleted.
    • Nickel sulfate patch tests remained positive, though less local therapy was required.
    • The correlation between eczema activity and urinary nickel concentration lost its periodicity.

    Implications:

    • The efficacy of DDC in reducing nickel exposure for hypersensitive individuals remains uncertain.
    • Further studies are required to determine if DDC is beneficial for managing nickel hypersensitivity.
    • DDC's role in mitigating nickel exposure from dietary and environmental sources needs clarification.

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