The GUDMAP database--an online resource for genitourinary research

Area of Science:

• Developmental Biology
• Genitourinary System Research
• Molecular Anatomy

Background:

• The developing genitourinary (GU) system is complex, requiring detailed molecular understanding.
• Existing data resources may lack the resolution or accessibility needed for comprehensive analysis.

Purpose of the Study:

• To establish the GenitoUrinary Development Molecular Anatomy Project (GUDMAP) as a central resource.
• To provide high-resolution gene expression data for the developing mouse GU system.
• To facilitate research in urogenital system development.

Main Methods:

• Large-scale in situ hybridisation screens (wholemount and section).
• Microarray gene expression profiling of microdissected, laser-captured, and FACS-sorted GU components.
• Annotation using a high-resolution anatomy ontology specific to the developing murine GU system.

Main Results:

• Generation of a comprehensive gene expression dataset for the developing mouse GU system.
• Development of user-friendly interfaces for data accessibility at www.gudmap.org.
• Demonstration of data utility through examples in developmental biology research.

Conclusions:

• GUDMAP offers a powerful, curated, high-resolution dataset for researchers.
• The freely accessible data resource supports diverse investigations in urogenital development.
• The project serves as a valuable primer for utilizing developmental biology databases.