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Related Concept Videos

Microbiota of the Urogenital Tract01:28

Microbiota of the Urogenital Tract

The human urogenital system, once thought to be sterile in healthy individuals, is now recognized as a complex microbial habitat. Advancements in molecular sequencing techniques have revealed that even in healthy adults, the kidneys and bladder harbor microbial populations similar to those found in the distal urethra, albeit in much lower abundance. These resident microorganisms, while generally innocuous, can become opportunistic pathogens under conditions that alter the urogenital...
Anatomy of the Genitourinary System II: Bladder and Urethra01:19

Anatomy of the Genitourinary System II: Bladder and Urethra

The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
Anatomy of the Genitourinary System I: Kidneys and Ureters01:11

Anatomy of the Genitourinary System I: Kidneys and Ureters

The upper urinary system comprises two kidneys and two ureters, which are crucial in filtering blood and forming urine.KidneysLocation and Structure:The kidneys are two bean-shaped organs positioned behind the peritoneum on either side of the spine.Kidneys are between the 12th thoracic (T12) and the 3rd lumbar (L3) vertebrae.The position of the liver causes the right kidney to sit slightly lower than the left.Protective Layers:Each kidney is enveloped in a tough, fibrous membrane called the...
Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
Imaging Studies I: Kidney, Ureter, and Bladder Studies01:28

Imaging Studies I: Kidney, Ureter, and Bladder Studies

Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...

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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
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Published on: August 15, 2019

The GUDMAP database--an online resource for genitourinary research.

Simon D Harding1, Chris Armit, Jane Armstrong

  • 1MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK. sharding@hgu.mrc.ac.uk

Development (Cambridge, England)
|June 10, 2011
PubMed
Summary

The GenitoUrinary Development Molecular Anatomy Project (GUDMAP) provides gene expression data for the developing mouse genitourinary system. This accessible resource aids research in developmental biology and urogenital system studies.

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Area of Science:

  • Developmental Biology
  • Genitourinary System Research
  • Molecular Anatomy

Background:

  • The developing genitourinary (GU) system is complex, requiring detailed molecular understanding.
  • Existing data resources may lack the resolution or accessibility needed for comprehensive analysis.

Purpose of the Study:

  • To establish the GenitoUrinary Development Molecular Anatomy Project (GUDMAP) as a central resource.
  • To provide high-resolution gene expression data for the developing mouse GU system.
  • To facilitate research in urogenital system development.

Main Methods:

  • Large-scale in situ hybridisation screens (wholemount and section).
  • Microarray gene expression profiling of microdissected, laser-captured, and FACS-sorted GU components.
  • Annotation using a high-resolution anatomy ontology specific to the developing murine GU system.

Main Results:

  • Generation of a comprehensive gene expression dataset for the developing mouse GU system.
  • Development of user-friendly interfaces for data accessibility at www.gudmap.org.
  • Demonstration of data utility through examples in developmental biology research.

Conclusions:

  • GUDMAP offers a powerful, curated, high-resolution dataset for researchers.
  • The freely accessible data resource supports diverse investigations in urogenital development.
  • The project serves as a valuable primer for utilizing developmental biology databases.