Acute intoxication with the adjuvant itself for Gramoxone INTEON
1Department of Emergency Medicine, Chonnam National University Medical School, Gwangju, South Korea.
Human & Experimental Toxicology
|June 10, 2011
Summary
Acute adjuvant intoxication from Gramoxone INTEON can cause gastrointestinal and cardiovascular symptoms, including QTc prolongation. Prompt supportive care led to full recovery in all seven patients, highlighting the need to consider methanol toxicity.
Area of Science:
- Toxicology
- Clinical Medicine
- Environmental Health
Background:
- Gramoxone INTEON is a widely used herbicide.
- The adjuvant contains methanol, a potential toxin.
- No previous studies characterized the acute toxicity of this specific adjuvant.
Observation:
- Seven patients ingested 20-150 mL of the adjuvant.
- Common symptoms included nausea and vomiting.
- Cardiovascular effects observed were QTc prolongation and sinus tachycardia.
Findings:
- All patients exhibited elevated serum osmolar gap and lactate levels.
- One patient developed high anion gap metabolic acidosis, treated with sodium bicarbonate.
- No deaths or long-term sequelae were reported.
Implications:
- Physicians should consider methanol intoxication in cases of adjuvant poisoning.
- Supportive treatment is effective for acute adjuvant intoxication.
- Further research into herbicide adjuvant toxicity is warranted.
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