Related Experiment Video

Updated: Jun 1, 2026

Electromechanical Assessment of Optogenetically Modulated Cardiomyocyte Activity
12:52

Electromechanical Assessment of Optogenetically Modulated Cardiomyocyte Activity

Published on: March 5, 2020

Repolarization of the mammalian heart action potential is modulated by changes in osmotic strength

Umberto Banderali, Martin Fink, Wayne R Giles

    Cardiovascular Research
    |June 10, 2011
    PubMed
    Abstract

    No abstract available in PubMed .

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    The resting membrane potential of a neuron (-70mV) is sustained due to the selective ion permeability of the membrane. At the resting potential, the membrane is slightly permeable to ions like sodium (Na+) and chloride (Cl−) and highly permeable to potassium ions (K+). Differences in the ions' concentration inside the cell compared to the outside are maintained by membrane transport proteins like channels and pumps.
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    Action Potential01:14

    Action Potential

    Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
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