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Updated: Jun 1, 2026

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In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
Published on: August 12, 2017
Transplantation tolerance: memories that haunt us
Mandy L Ford1, Christian P Larsen
1Emory Transplant Center, Atlanta, GA 30322, USA.
Science Translational Medicine
|June 10, 2011
Summary
Transplant tolerance is achievable in mice but not primates. A high frequency of graft-reactive memory T cells may prevent tolerance induction in primates, leading to rejection.
Area of Science:
- Immunology
- Transplantation Science
- Cellular Biology
Background:
- Transplant tolerance, enabling graft acceptance without immunosuppression, is established in mice but remains elusive in primates.
- Allogeneic graft acceptance without immunosuppression is a major goal in transplantation.
Discussion:
- A high pretransplant frequency of graft-reactive memory T cells may impede transplant tolerance induction in nonhuman primates.
- This elevated T cell frequency is linked to transplant rejection in primate models.
Key Insights:
- Graft-reactive memory T cell frequency is a critical factor influencing transplant tolerance in primates.
- Understanding this frequency can guide donor organ selection and tolerance induction strategies.
Outlook:
- Measuring allograft-specific memory T cell frequency could inform clinical decisions in transplantation.
- This insight may lead to improved strategies for achieving transplant tolerance and reducing rejection.
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