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Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients

Published on: March 1, 2024

An unusual cause for sicca syndrome.

U P Kulkarni¹, Y A Gokhale, P M Raut

¹Department of Medicine, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, India. upk30@rediffmail.com

Journal of Postgraduate Medicine

|June 10, 2011

Summary

A rare case shows smouldering myeloma (MM) presenting as Sjögren's syndrome (SS). Early diagnosis via serum electrophoresis is crucial, as MM symptoms, like sicca, can resolve with anti-myeloma treatment.

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Area of Science:

Rheumatology
Hematology
Oncology

Background:

Sjögren's syndrome (SS) is an autoimmune disorder primarily affecting exocrine glands.
Patients with SS often exhibit circulating monoclonal immunoglobulins.
Smouldering myeloma (MM) is an asymptomatic plasma cell disorder.

Observation:

A 47-year-old female presented with three months of sicca symptoms, diagnosed as primary SS.
Serum electrophoresis revealed an M band and elevated gamma globulin (46 g/L).
Bone marrow aspiration showed 28% plasma cells, leading to an MM diagnosis due to absence of organ damage.

Findings:

The patient received treatment with thalidomide and dexamethasone for MM.
Sicca symptoms resolved following the anti-myeloma therapy.
This case suggests MM can rarely present as SS, with symptoms improving upon MM treatment.

Implications:

Highlights the importance of serum electrophoresis in diagnosing SS to detect underlying MM.
Demonstrates that sicca symptoms can be an initial manifestation of MM.
Underscores the need for a thorough hematological workup in SS patients, especially with rapid symptom onset or specific M band findings.