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Apparent diffusion coefficient values measured by diffusion-weighted imaging predict chemoradiotherapeutic effect for
Tomoyoshi Aoyagi1, Kiyohiko Shuto, Shinichi Okazumi
1Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba-shi, Japan.
Digestive Surgery
|June 10, 2011
Summary
Apparent diffusion coefficient (ADC) values in esophageal squamous cell carcinoma (ESCC) can predict treatment response and patient survival. Higher ADC values indicate a better response to chemoradiotherapy (CRT) and improved prognosis.
Area of Science:
- Radiology
- Oncology
- Medical Imaging
Background:
- Esophageal squamous cell carcinoma (ESCC) is a significant health concern.
- Predicting treatment response and prognosis in ESCC is crucial for patient management.
Purpose of the Study:
- To evaluate if apparent diffusion coefficient (ADC) values can predict chemoradiotherapy (CRT) response in ESCC.
- To determine if ADC values correlate with patient survival in ESCC.
Main Methods:
- Diffusion-weighted magnetic resonance imaging (MRI) was used to calculate ADC values in 80 ESCC patients before CRT.
- Patients were categorized into high-ADC and low-ADC groups based on pre-treatment ADC values.
- Statistical analyses included ROC analysis, Kaplan-Meier survival analysis, and log-rank tests.
Main Results:
- A high-ADC group demonstrated a significantly better response to CRT compared to the low-ADC group (p < 0.01).
- The high-ADC group exhibited a significantly better survival rate than the low-ADC group (p = 0.04).
- Average ADC value for esophageal cancer tissue was 1.10 × 10(-3) mm2/s.
Conclusions:
- ADC value is a potential imaging biomarker for predicting CRT treatment response in ESCC.
- ADC value may serve as a prognostic marker for survival in patients with ESCC.
