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Thermosensation

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...

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Related Experiment Video

Updated: Jun 1, 2026

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

Dissecting TRPV1: lessons to be learned?

Christian Grimm¹, Eduardo Aneiros, Marcel de Groot

¹Pain Research Unit, Pfizer Global Research and Development, Sandwich Laboratories, Kent, UK. Christian.Grimm2@pfizer.com

Channels (Austin, Tex.)

|June 10, 2011

Summary

This summary is machine-generated.

Transient Receptor Potential Vanilloid 1 (TRPV1) channels are key pain targets. Understanding their activation by heat and protons is crucial for developing safer pain relief drugs without side effects like hyperthermia.

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Purification and Reconstitution of TRPV1 for Spectroscopic Analysis

Purification and Reconstitution of TRPV1 for Spectroscopic Analysis

Published on: July 3, 2018

Related Experiment Videos

Last Updated: Jun 1, 2026

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

Purification and Reconstitution of TRPV1 for Spectroscopic Analysis

Purification and Reconstitution of TRPV1 for Spectroscopic Analysis

Published on: July 3, 2018

Area of Science:

Neuroscience
Molecular Biology
Pharmacology

Background:

Transient Receptor Potential Vanilloid 1 (TRPV1) is a polymodal nociceptor.
TRPV1 is expressed in sensory neurons and implicated in epithelial functions.
TRPV1 is a significant drug target for pain conditions.

Purpose of the Study:

To review the molecular determinants of TRPV1 channel activation.
To discuss newly discovered activation sites and their drug discovery implications.

Main Methods:

Literature review of TRPV1 channel activation mechanisms.
Analysis of molecular determinants for heat, proton, and capsaicin activation.

Main Results:

Identified specific heat and proton activation sites within the TRPV1 pore domain.
TRPV1 antagonists can cause species-dependent hyperthermia in vivo.

Conclusions:

Understanding TRPV1 activation sites is vital for drug discovery.
Developing euthermic TRPV1 antagonists with selective profiles is essential for therapeutic success.