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Herpes simplex virus interstitial nephritis in a renal allograft
P L Silbert1, L R Matz, K Christiansen
1Department of Nephrology, Royal Perth Hospital, Australia.
Clinical Nephrology
|June 1, 1990
Summary
Herpes simplex virus type 1 caused interstitial nephritis in a kidney transplant recipient. The infection led to poor graft function, necessitating transplant nephrectomy and confirming the virus
Area of Science:
- Nephrology
- Virology
- Transplant Surgery
Background:
- Kidney transplantation is a life-saving procedure for end-stage renal disease.
- Post-transplant complications can include infections affecting graft survival.
Observation:
- A 35-year-old woman developed interstitial nephritis after a cadaveric renal transplant.
- The patient experienced poor initial transplant function.
Findings:
- Renal biopsy revealed histological changes consistent with herpes simplex virus (HSV) infection.
- Immunoperoxidase staining confirmed HSV presence in the renal tissue.
- Herpes simplex virus type 1 was successfully cultured from the explanted kidney.
Implications:
- Herpes simplex virus type 1 can be a cause of interstitial nephritis in renal transplant recipients.
- Early diagnosis and management of HSV infection are crucial for graft and patient outcomes.
- This case highlights the importance of considering viral infections in non-functioning kidney transplants.
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