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Updated: Jun 1, 2026

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation

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Published on: August 19, 2020

Myeloproliferative neoplasms cause glomerulopathy.

Samar M Said¹, Nelson Leung, Sanjeev Sethi

¹Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.

Kidney International

|June 10, 2011

Summary

Glomerulopathy is a late complication of myeloproliferative neoplasms, especially primary myelofibrosis. This kidney disease often leads to persistent renal dysfunction and end-stage renal disease, requiring greater awareness and research into therapies.

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Area of Science:

Nephrology
Hematology
Oncology

Background:

Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell disorders.
MPNs can manifest with an undefined glomerulopathy, a kidney disease affecting the glomeruli.
The specific characteristics and prognosis of MPN-related glomerulopathy require further elucidation.

Purpose of the Study:

To characterize the histological features and clinical outcomes of glomerulopathy in patients with myeloproliferative neoplasms.
To identify specific patterns of kidney disease associated with different types of MPNs.

Main Methods:

Retrospective evaluation of 11 patients diagnosed with myeloproliferative neoplasm-related glomerulopathy.
Analysis of kidney biopsy findings, including mesangial sclerosis, hypercellularity, segmental sclerosis, chronic thrombotic microangiopathy, and intracapillary hematopoietic cells.
Review of clinical data, including indications for biopsy, time from MPN diagnosis to biopsy, and renal function on follow-up.

Main Results:

All 11 patients exhibited mesangial sclerosis and hypercellularity.
Segmental sclerosis was observed in 8 cases, and chronic thrombotic microangiopathy features in 9.
Four patients progressed to end-stage renal disease (ESRD), and seven had persistent renal dysfunction.

Conclusions:

Glomerulopathy is a significant and often late-stage complication of myeloproliferative neoplasms, particularly primary myelofibrosis.
The prognosis for renal function in these patients is guarded, with a high risk of progression to ESRD.
Increased clinical awareness and further research are necessary to develop effective therapeutic strategies for MPN-related glomerulopathy.