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Related Concept Videos

Molar Mass01:54

Molar Mass

The identity of a substance is defined not only by the types of atoms or ions it contains but by the quantity of each type of atom or ion. For example, water, H2O, and hydrogen peroxide, H2O2, are alike in that their respective molecules are composed of hydrogen and oxygen atoms. However, because a hydrogen peroxide molecule contains two oxygen atoms, as opposed to the water molecule, which has only one, the two substances exhibit very different properties.
The Fluid Mosaic Model01:34

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The fluid mosaic model was first proposed as a visual representation of research observations. The model comprises the composition and dynamics of membranes and serves as a foundation for future membrane-related studies. The model depicts the structure of the plasma membrane with a variety of components, which include phospholipids, proteins, and carbohydrates. These integral molecules are loosely bound, defining the cell’s border and providing fluidity for optimal function.
Fluid Mosaic Model01:19

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Scientists identified the plasma membrane in the 1890s and its principal chemical components (lipids and proteins) by 1915. The model for plasma membrane structure, proposed in 1935 by Hugh Davson and James Danielli, was the first model to be widely accepted in the scientific community. The model was based on the plasma membrane's "railroad track" appearance in early electron micrographs. Davson and Danielli theorized that the plasma membrane's structure resembled a sandwich with the analogy of...
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Kinetic Theory of an Ideal Gas01:12

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Hückel's Rule Diagram of π MOs: Frost Circle01:08

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The Frost circle or the inscribed polygon method is a graphical method for determining the relative energies of π molecular orbitals (MOs) for planar, fully conjugated, and monocyclic compounds. This method was first described by A. A. Frost and Boris Musulin in 1953.
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Preparation of Mica Supported Lipid Bilayers for High Resolution Optical Microscopy Imaging
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Published on: June 7, 2014

Mosaics and moles.

Lone Sunde1, Isa Niemann, Estrid Staehr Hansen

  • 1Department of Clinical Genetics, Aarhus University Hospital, Aalborg, Denmark. l.sunde@rn.dk

European Journal of Human Genetics : EJHG
|June 10, 2011
PubMed
Summary
This summary is machine-generated.

Diploid moles can arise from postzygotic abnormalities, not just fertilization of an empty egg. Most cases involve mosaicism with both maternal and paternal genomes, suggesting new origins for androgenetic cell populations.

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Area of Science:

  • Reproductive Biology
  • Genetics
  • Human Embryology

Background:

  • Hydatidiform mole (HM) is an abnormal pregnancy characterized by placental vesicular swelling.
  • Most HMs are diploid androgenetic or triploid, but some diploid moles exhibit both maternal and paternal genomes.
  • Previous work identified 11 diploid moles with biparental markers among 162 cases.

Purpose of the Study:

  • To perform detailed DNA-marker analysis on 11 diploid moles with suspected biparental origins.
  • To investigate the cellular composition and potential origins of these rare diploid moles.

Main Methods:

  • Analysis of DNA markers in tissue and single cells from 11 diploid hydatidiform moles.
  • Identification and characterization of distinct cell populations within the moles.

Main Results:

  • 3 out of 11 moles contained only biparental cells.
  • 8 out of 11 moles showed mosaicism, with both biparental and androgenetic cell populations.
  • One mosaic mole was associated with persistent trophoblastic disease (PTD).

Conclusions:

  • Mosaic conceptuses with androgenetic cells likely result from postzygotic abnormalities, not solely fertilization of an empty oocyte.
  • These findings challenge traditional views on androgenetic cell population origins in moles.
  • Further study of mosaic conceptuses can illuminate early human development and fertilization processes.