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Related Experiment Video

Updated: Jun 1, 2026

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

MicroRNAs in cardiovascular disease.

Terry S Elton, Mahmood Khan, Dmitry Terentyev

F1000 Medicine Reports

|June 10, 2011

Summary

Diagnosing heart attacks requires quick and precise methods. Mature microRNAs (miRNAs) in blood plasma show promise as reliable biomarkers for assessing cardiac damage and improving patient care.

Area of Science:

Biochemistry
Molecular Biology
Cardiology

Background:

Accurate diagnosis and damage assessment are crucial for effective coronary care.
Mature microRNAs (miRNAs) are stable, measurable molecules found in blood plasma.
Potential for non-invasive biomarkers in routine clinical practice.

Purpose of the Study:

To explore the potential of mature microRNAs (miRNAs) as biomarkers for heart attack diagnosis and damage assessment.
To evaluate the feasibility of using peripheral blood miRNAs for routine clinical cardiac assessments.

Main Methods:

Analysis of mature microRNAs (miRNAs) in blood plasma samples.
Assessment of miRNA stability and abundance.
Correlation of miRNA levels with heart attack diagnosis and damage.

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Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Published on: September 15, 2018

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Last Updated: Jun 1, 2026

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Published on: September 15, 2018

Main Results:

Mature microRNAs (miRNAs) are abundant and stable in blood plasma.
miRNA levels may be indicative of specific disease states, including heart attacks.
Peripheral blood miRNA measurements offer a potentially attractive method for clinical assessment.

Conclusions:

Mature microRNAs (miRNAs) represent a promising, non-invasive biomarker source for cardiac conditions.
Further research into miRNAs could significantly advance routine clinical diagnostics for heart attacks and related damage.
The stability and accessibility of miRNAs in plasma support their potential role in improving coronary care.