Related Experiment Video
Updated: Jun 1, 2026

Three Strategies to Induce Neurotrophic Keratitis and Nerve Regeneration in Murine Cornea
Published on: December 8, 2023
Neurotrophic corneal ulcer development following cataract surgery with a limbal relaxing incision
Sang-Woong Moon1, Dong-Ju Yeom, So-Hyang Chung
1Department of Ophthalmology, East-West Neo Medical Center, Kyung Hee University School of Medicine, Seoul, Korea.
Abstract:
A 60-year-old man with bilateral corneal opacity underwent cataract extraction surgery involving the use of a limbal relaxing incision in his left eye. He had lower lid ectropion and lagophthalmos in both eyes. Eleven days after the surgery, a slit-lamp examination revealed a neurotrophic corneal ulcer with a punch-out epithelial defect and rolled edges at the center of the pre-existing corneal opacity. The patient was treated with sodium hyaluronate, autologous serum, and oral doxycycline. Six weeks after the surgery an improvement in corneal sensation was observed and the neurotrophic corneal ulcer subsequently healed over the course of one year. In this report, we present a case of neurotrophic keratitis that occurred after performing cataract surgery concurrent with a limbal relaxing incision. As such, we suggest that limbal relaxing incisions should be performed cautiously in patients with causative risk factors for corneal hypesthesia.

