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Effective use of polymyxin B hemoperfusion in septic shock complicated by urosepsis

P Malleshappa1, R Ranganath, A P Chaudhari

  • 1Department of Nephrology, Lilavati Hospital and Research Centre, Mumbai, India.

Indian Journal of Nephrology
|June 10, 2011
PubMed

Insights

Polymyxin B-immobilized fiber direct hemoperfusion (PMX-DHP) successfully treated septic shock from urosepsis. This innovative therapy improved cardiovascular stability and led to patient recovery in India.

Area of Science:

  • Nephrology
  • Critical Care Medicine
  • Infectious Diseases

Background:

  • Septic shock from Gram-negative infections is a life-threatening condition.
  • Polymyxin B-immobilized fiber direct hemoperfusion (PMX-DHP) is an established treatment for septic shock.
  • Urosepsis is a common cause of Gram-negative septic shock.

Observation:

  • A patient presented with septic shock secondary to urosepsis.
  • The patient received antibiotic therapy followed by PMX-DHP.
  • Cardiovascular stability was monitored during and after the procedure.

Findings:

  • PMX-DHP therapy was successfully administered to the patient.
  • The treatment resulted in improved cardiovascular stability.
  • The patient recovered from septic shock within days of PMX-DHP treatment.

Implications:

  • This case highlights the potential efficacy of PMX-DHP in managing urosepsis-induced septic shock.
  • This represents the first reported use of PMX-DHP for urosepsis with septic shock in India.
  • Further research may explore PMX-DHP as a therapeutic option for similar complex cases.
Keywords:
Gram-negative infectionPMX-DHPSeptic shockurosepsis

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