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Increased insensible water loss contributes to aging related dehydration
Natalia I Dmitrieva1, Maurice B Burg
1Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America. dmitrien@nhlbi.nih.gov
Plos One
|June 10, 2011
Summary
Aging increases dehydration risk due to greater insensible water loss from skin and respiration, even before reduced urine concentration occurs in older mice.
Area of Science:
- Gerontology
- Physiology
- Animal Models
Background:
- Dehydration in aging is linked to reduced thirst and urine concentrating ability.
- Older adults are more susceptible to dehydration, impacting health and well-being.
Purpose of the Study:
- To investigate age-related changes in water balance and urine concentration in mice.
- To identify the primary mechanisms contributing to dehydration in aging.
Main Methods:
- Comparison of urine concentration and water balance in 3, 18, and 27-month-old mice under water restriction.
- Measurement of body weight, urine osmolality, and vasopressin levels.
- Assessment of water balance when consuming gel food with controlled water content.
Main Results:
- Young mice maintained water balance, while older mice exhibited negative water balance (weight loss).
- Older mice showed increased vasopressin excretion, indicating dehydration.
- Insensible water loss (respiratory and skin) increased with age, preceding decreased urine concentrating ability.
Conclusions:
- Increased insensible water loss is a significant contributor to dehydration in aging mice.
- Age-related dehydration mechanisms involve both altered urine output and increased extra-urinary water loss.
- Insensible water loss emerges as an earlier factor in aging-related dehydration than reduced urine concentrating capacity.
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