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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

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Related Experiment Video

Updated: Jun 1, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Epigenetic changes in cancer.

Manel Esteller1

  • 1Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL) 08908 L'Hospitalet de Llobregat, Barcelona, Catalonia Spain.

F1000 Biology Reports
|June 10, 2011
PubMed
Summary
This summary is machine-generated.

Epigenetics research is rapidly advancing, particularly in cancer. Future human cancer epigenome data will drive development of novel biomarkers and epigenetic therapies.

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Last Updated: Jun 1, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

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Published on: April 5, 2018

Methylated DNA Immunoprecipitation
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Area of Science:

  • Biomedical research
  • Cancer epigenetics
  • Molecular biology

Background:

  • Epigenetics has gained significant traction in biomedical fields, originating in cancer research.
  • Key milestones include DNA hypomethylation (1980s), CpG island hypermethylation (1990s), and drug approvals (2000s).
  • Current research encompasses histone modifications and noncoding RNA interactions in transformed cells.

Purpose of the Study:

  • To highlight the expanding scope of epigenetics in biomedical research.
  • To emphasize the historical progression of epigenetic discoveries in cancer.
  • To forecast future directions in cancer epigenome research.

Main Methods:

  • Review of historical epigenetic findings in cancer.
  • Discussion of current research trends in epigenetics.
  • Anticipation of future research based on epigenome completion.

Main Results:

  • Epigenetics has evolved from DNA methylation to include histone modifications and noncoding RNAs.
  • Significant progress has been made in understanding epigenetic alterations in cancer.
  • Completion of human cancer epigenomes is imminent.

Conclusions:

  • The field of epigenetics is rapidly expanding across biomedical disciplines.
  • Upcoming human cancer epigenome data holds promise for improved diagnostics and therapeutics.
  • Further research into histone modifications and noncoding RNAs is crucial for advancing epigenetic therapies.