Related Experiment Video
Updated: Mar 30, 2026
![Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60445.jpg&w=3840&q=50)
04:12
Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
Published on: December 19, 2019
15.7K
Skin tumors in childhood
1Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie,Universitätsklinikum Würzburg. Hamm_H@klinik.uni-wuerzburg.de
Deutsches Arzteblatt International
|June 10, 2011
Summary
Pediatric skin tumors are rarely malignant, but certain signs warrant evaluation. Understanding tumor behavior aids in appropriate treatment decisions for children.
Area of Science:
- Pediatric Dermatology
- Oncology
- Dermatopathology
Background:
- Parents frequently seek medical advice for pediatric skin tumors.
- Accurate diagnosis is crucial for appropriate management.
Purpose of the Study:
- To provide guidance on evaluating and managing pediatric skin tumors.
- To differentiate between benign and malignant pediatric skin lesions.
Main Methods:
- Selective literature review of pediatric skin tumors.
Main Results:
- Malignant skin tumors are uncommon in children (1-2% of excised lesions).
- Warning signs for malignancy include rapid growth, firm consistency, large diameter, ulceration, immobility, and neonatal presence.
- Common adult skin cancers are rare in children; congenital nevi have lower malignant potential.
- Spitz nevi can mimic melanoma; some benign tumors may spontaneously regress.
- Propranolol shows promise for infantile hemangiomas over corticosteroids.
Conclusions:
- Specialized knowledge is essential for physicians to determine the optimal management strategy for pediatric skin tumors.
- Treatment options range from excision and non-surgical methods to observation or further evaluation.
Related Concept Videos
01:27Acne Infection
48
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
48
01:30Skin Cancer
6.6K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
6.6K
01:20The Retinoblastoma Gene
4.9K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.9K
01:20The Retinoblastoma Gene
2.8K
No description available
2.8K
01:23Skin Diseases and Disorders
6.1K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
6.1K
01:19Pigmentation
5.0K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
5.0K