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Echocardiographic parameters of epicardial fat deposition and its relation to coronary artery disease
Juan Valiente Mustelier1, Julio Oscar Cabrera Rego, Angela Gala González
1National Cardiology and Cardiovascular Surgery Institute, Havana, Cuba.
Insights
Epicardial fat and right ventricle fat infiltration are linked to coronary artery disease (CAD) presence in Hispanic patients. Increased cardiac fat deposition proportionally elevates CAD risk.
Area of Science:
- Cardiology
- Medical Imaging
- Public Health
Background:
- Epicardial fat is linked to coronary artery disease (CAD).
- Associations of atrial septum lipomatosis and right ventricle fat infiltration with CAD are unclear.
- These cardiac fat parameters lack study in Hispanic populations.
Purpose of the Study:
- To investigate the association between epicardial fat, atrial septum lipomatosis, right ventricle fat infiltration, and CAD presence.
- To evaluate these associations specifically within a Hispanic patient cohort.
Main Methods:
- Study included 250 Hispanic patients undergoing first invasive coronary angiography.
- Cardiac fat deposition was assessed via 2D-echocardiography post-angiography.
- Clinical and anthropometric data, including age, sex, risk factors, and BMI, were collected.
Main Results:
- Epicardial fat and right ventricle fat infiltration showed significant, independent association with CAD presence.
- The extent of epicardial fat deposition was proportionally associated with CAD presence.
- No significant association was found between these fat parameters and CAD extent or clinical presentation.
Conclusions:
- Epicardial fat and right ventricle fat infiltration are significant independent predictors of CAD presence.
- Cardiac fat deposition extent is proportionally related to the likelihood of having CAD.
- Findings highlight the role of specific cardiac fat depots in CAD risk among Hispanic individuals.
Background:
Epicardial fat has been associated to the presence of significant coronary artery disease (CAD). However, the association of lipomatous infiltration of the atrial septum and fat infiltration of the right ventricle remains uncertain. None of these parameters has been thoroughly studied in Hispanic patients.
Objective:
To determine the association between epicardial fat, lipomatous infiltration of the atrial septum and fat infiltration of the right ventricle with the presence of CAD.
Methods:
Two hundred and fifty Hispanic patients (86 women and 164 men, mean age 61.5 ± 8 vs 62 ± 10 respectively), undergoing their first invasive coronary angiography (ICA) were studied. The day after the ICA, parameters of cardiac fat deposition were evaluated using 2D-echocardiography. Clinical (age, sex, personal antecedents of smoking habit, hypertension and diabetes mellitus, as well as clinical presentation of CAD) and anthropometric (waist circumference and body mass index [BMI]) variables were also collected.
Results:
Epicardial fat (OR 1.27 p = 0.009), as well as fat infiltration of the right ventricle (OR 2.94 p = 0.027), had a significant and independent association with the presence, but not the extent (p = 0.516) and clinical presentation (p = 0.153) of CAD. The extent of epicardial fat deposition showed a proportional and significant association (p = 0.001) with the presence of CAD.
Conclusion:
Epicardial fat and fat infiltration of the right ventricle were both significant and independent factors associated to the presence of CAD, which was proportionally increased according to the extent of cardiac fat deposition.
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