Collagenous spherulosis. A comment on its histogenesis

Area of Science:

• Pathology
• Oncology
• Histology

Background:

• Collagenous spherulosis is a benign breast lesion.
• It involves lobular acini and ductules with eosinophilic spherules.
• The lesion is considered a myoepithelial product.

Purpose of the Study:

• To describe collagenous spherulosis.
• To report similar lesions in salivary gland tumors.
• To identify analogous lesions in benign lymphoepithelial lesions of the parotid gland.

Main Methods:

• Histopathological examination of breast tissue.
• Comparative analysis of lesions in salivary glands and parotid glands.
• Microscopic evaluation of eosinophilic spherules.

Main Results:

• Collagenous spherulosis characterized by eosinophilic spherules up to 100 mu observed in breast tissue.
• Similar collagenous spherulosis-like lesions identified in salivary gland tumors.
• Analogous findings in a benign lymphoepithelial lesion of the parotid gland.

Conclusions:

• Collagenous spherulosis is a distinct benign breast lesion.
• Myoepithelial cell-related changes can manifest as collagenous spherulosis in salivary glands.
• Recognition of these similar lesions is important for accurate diagnosis.