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Related Experiment Video

Updated: Jun 1, 2026

Construction and Application of Cerebral Functional Region-Based Cerebral Blood Flow Atlas Using Magnetic Resonance Imaging-Arterial Spin Labeling

Construction and Application of Cerebral Functional Region-Based Cerebral Blood Flow Atlas Using Magnetic Resonance Imaging-Arterial Spin Labeling

Published on: May 31, 2024

Arterial spin labeling angiography using a triple inversion recovery prepulse.

Marcelo E Andia¹, Rene M Botnar

¹Division of Imaging Sciences and Biomedical Engineering, King's College London, St Thomas' Hospital, London, United Kingdom. marcelo.andia_kohnenkampf@kcl.ac.uk

Magnetic Resonance in Medicine

|June 10, 2011

Summary

A novel triple-inversion-recovery sequence-arterial spin labeling method enhances noninvasive angiography. This technique reduces scan times and improves image quality by eliminating the need for subtraction and complex planning.

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Last Updated: Jun 1, 2026

Construction and Application of Cerebral Functional Region-Based Cerebral Blood Flow Atlas Using Magnetic Resonance Imaging-Arterial Spin Labeling

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Published on: May 31, 2024

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Assessment of Cardiac Function and Myocardial Morphology Using Small Animal Look-locker Inversion Recovery (SALLI) MRI in Rats

Assessment of Cardiac Function and Myocardial Morphology Using Small Animal Look-locker Inversion Recovery (SALLI) MRI in Rats

Published on: July 19, 2013

Area of Science:

Medical Imaging
Radiology
Biophysics

Background:

Arterial spin labeling (ASL) is a noninvasive angiography technique that avoids contrast agents.
Clinical adoption of ASL is limited by long scan times, sensitivity to misregistration, and complex planning for optimal blood-to-background contrast.

Purpose of the Study:

To introduce a new ASL method using a triple-inversion-recovery sequence.
To overcome the limitations of conventional ASL, enabling easier clinical application.

Main Methods:

Developed a novel ASL technique employing a triple-inversion-recovery sequence.
Utilized two nonselective inversion recovery prepulses to suppress background signal across various T1 values.
Employed a third slab-selective inversion pulse to preserve the signal from labeled blood.

Main Results:

The proposed method effectively nulls background signal, allowing for flexible inversion delay selection.
Acquisition of angiograms without the need for image subtraction, mitigating sensitivity to spatial misregistration.
Simplified planning procedure compared to traditional ASL methods.

Conclusions:

The triple-inversion-recovery sequence-ASL offers a more practical and robust approach to noninvasive angiography.
This technique addresses key challenges, potentially increasing the clinical utility of ASL.