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Related Experiment Videos

Naloxone and intestinal motility.

R A Howd, A Adamovics, A Palekar

    Experientia
    |October 15, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Post-surgery intestinal paralysis may not be caused by endorphins. Naloxone, an opiate antagonist, did not block this effect in rats, questioning the role of intestinal endorphins in surgical recovery.

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    Area of Science:

    • Gastroenterology
    • Neuroscience
    • Pharmacology

    Background:

    • Abdominal surgery can lead to inhibited intestinal peristalsis.
    • This inhibition is hypothesized to be linked to endogenous opiate agonists (endorphins) released during surgical stress.

    Purpose of the Study:

    • To investigate the role of endorphins in post-operative intestinal peristalsis inhibition.
    • To determine if endorphin antagonism can reverse this inhibition.

    Main Methods:

    • Administration of naloxone, a known endorphin antagonist, to rats following abdominal surgery.
    • Observation and measurement of intestinal peristalsis in treated rats.

    Main Results:

    • Naloxone failed to block or reverse the inhibition of intestinal peristalsis.

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  • The findings indicate that endorphins are not the primary mediators of this post-surgical effect.

    • Conclusions:

    • The hypothesis linking endorphin release to post-operative intestinal paralysis is not supported by these findings.
    • The precise mechanism of intestinal peristalsis inhibition after surgery remains unclear.
    • The functional significance of intestinal endorphins warrants further investigation.