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Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
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Published on: January 7, 2019

Flurbiprofen encapsulation using pluronic triblock copolymers.

Shirin Alexander1, Terence Cosgrove, Stuart W Prescott

  • 1School of Chemistry, University of Bristol, Bristol BS8 1TS, United Kingdom. terence.cosgrove@bris.ac.uk

Langmuir : the ACS Journal of Surfaces and Colloids
|June 11, 2011
PubMed
Summary
This summary is machine-generated.

Adding flurbiprofen to pluronic triblock copolymers (P123, P103) lowers their critical micelle concentration (cmc) and enhances micellization. This indicates pluronic polymers effectively solubilize this nonsteroidal anti-inflammatory drug.

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Area of Science:

  • Physical Chemistry
  • Polymer Science
  • Materials Science

Background:

  • Pluronic triblock copolymers are widely used in drug delivery systems.
  • Understanding their micellization behavior is crucial for optimizing drug solubilization.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) often exhibit poor water solubility.

Purpose of the Study:

  • To investigate the impact of flurbiprofen on the micellization of Pluronic copolymers (P103, P123, L43).
  • To determine if Pluronic copolymers can effectively solubilize flurbiprofen.

Main Methods:

  • Pulsed-field gradient stimulated-echo nuclear magnetic resonance (PFG-STE-NMR) spectroscopy.
  • Surface tension measurements.
  • Analysis of critical micelle concentration (cmc) and hydrodynamic radius.

Main Results:

  • Addition of 0.6 wt% flurbiprofen reduced the cmc of Pluronic P123 and P103.
  • Flurbiprofen promoted micellization in Pluronic P123 and P103 solutions.
  • Hydrodynamic radius of Pluronic P103 increased from 5 to 10 nm, with a higher fraction of micellized polymer.

Conclusions:

  • Pluronic copolymers P123 and P103 effectively solubilize flurbiprofen.
  • Flurbiprofen addition enhances the micellization of these Pluronic copolymers.
  • These findings highlight the potential of Pluronics as drug carriers for NSAIDs.