Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cannabis dependence and tolerance production.

D R Compton1, W L Dewey, B R Martin

  • 1Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298.

Advances in Alcohol & Substance Abuse
|January 1, 1990
PubMed
Summary

Chronic cannabis use causes tolerance but physical dependence is not well-established. The main dangers of cannabis abuse stem from its effects on the central nervous system, not dependence.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Calcium-41: a technology for monitoring changes in bone mineral.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2016
Same author

A randomized trial of vitamin D₃ supplementation in children: dose-response effects on vitamin D metabolites and calcium absorption.

The Journal of clinical endocrinology and metabolism·2013
Same author

Racial differences in cortical bone and their relationship to biochemical variables in Black and White children in the early stages of puberty.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2012
Same author

Simple isotopic method using oral stable or radioactive tracers for estimating fractional calcium absorption in adult women.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2010
Same author

Validation of a simple isotope method for estimating true calcium fractional absorption in adolescents.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2010
Same author

Antiresorptive effects of phytoestrogen supplements compared with estradiol or risedronate in postmenopausal women using (41)Ca methodology.

The Journal of clinical endocrinology and metabolism·2009

Area of Science:

  • Pharmacology
  • Neuroscience
  • Addiction Research

Background:

  • Chronic drug abuse often leads to tolerance and physical dependence.
  • Cannabis (marijuana) exhibits tolerance in both animals and humans.
  • Physical dependence and withdrawal symptoms from cannabis are not well-defined.

Purpose of the Study:

  • To review the evidence for tolerance and physical dependence associated with chronic cannabis abuse.
  • To explore the challenges in studying cannabis dependence in animal models.
  • To assess the primary risks of cannabis abuse.

Main Methods:

  • Literature review of studies on cannabis tolerance and dependence.
  • Analysis of experimental animal and human data.
  • Discussion of the pharmacological effects of cannabis and delta-9-THC.

Main Results:

  • Tolerance to cannabis is consistently observed.
  • Evidence for significant cannabis withdrawal syndrome is limited and poorly defined.
  • Cannabis abuse potential is more evident in human studies than animal models, possibly due to drug properties.
  • The risks of cannabis abuse are more likely linked to its central nervous system and organ effects.

Conclusions:

  • Cannabis tolerance is well-documented.
  • Physical dependence on cannabis is not clearly established.
  • The primary risks of cannabis abuse are associated with its psychoactive and physiological effects, rather than dependence.

Related Experiment Videos