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Relationships between neural crest cells and catecholamine in suckling mice
Experientia
|October 15, 1978
Summary
L-isoproterenol hydrochloride induced neural crest tumors and cell death in mice. Neural crest derivatives may function as beta-receptor cells involved in cyclic AMP-mediated neurotransmission.
Area of Science:
- Developmental biology
- Neuroscience
- Pharmacology
Background:
- Neural crest cells are crucial for development.
- Beta-adrenergic receptors play roles in neurotransmission.
Purpose of the Study:
- To investigate the effects of L-isoproterenol hydrochloride on neural crest cells in vivo.
- To explore the potential role of neural crest derivatives in beta-receptor-mediated neurotransmission.
Main Methods:
- Suckling mice were injected intraperitoneally with L-isoproterenol hydrochloride (27 mg/kg).
- Tumor development and neural crest cell death were assessed.
Main Results:
- Multiple neural crest tumors developed in the treated mice.
- Significant cell death of neural crest cells was observed.
Conclusions:
- L-isoproterenol hydrochloride can induce neural crest tumors and cell death.
- Neural crest derivatives may possess beta-receptor activity and participate in cyclic AMP-regulated neurotransmission.