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Elevated plasma myeloperoxidase levels in relation to circulating inflammatory markers in coronary artery disease

Saed Ziaaldin Samsamshariat1, Gholam Basati, Ahmad Movahedian

  • 1Department of Clinical Biochemistry, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy & Pharmaceutical Sciences, Isfahan University of Medical Sciences, Iran.

Biomarkers in Medicine
|June 11, 2011
PubMed

Insights

Myeloperoxidase (MPO) levels are elevated in coronary artery disease (CAD) patients, correlating with oxidized LDL and reduced nitric oxide. This suggests MPO’s role in CAD pathogenesis through LDL oxidation and NO depletion.

Area of Science:

  • Cardiovascular Research
  • Biomarkers
  • Inflammation

Background:

  • The role of myeloperoxidase (MPO) in stable coronary artery disease (CAD) remains debated.
  • The association between MPO, oxidized low-density lipoprotein (ox-LDL), and nitrite/nitrate (NOx) in CAD patients is not well-established.

Purpose of the Study:

  • To investigate plasma MPO levels in stable CAD, unstable CAD, and control subjects.
  • To evaluate the relationship between MPO, ox-LDL, and NOx in CAD patients.

Main Methods:

  • Enzyme immunoassay was used to measure plasma MPO and ox-LDL levels.
  • Plasma NOx and other cardiovascular risk factors were assessed in 50 stable CAD patients, 50 unstable CAD patients, and 50 controls.

Main Results:

  • Plasma MPO levels were significantly higher in unstable CAD patients compared to stable CAD patients and controls (p < 0.001).
  • Plasma MPO showed a positive correlation with ox-LDL levels and a negative correlation with NOx levels (p < 0.05).

Conclusions:

  • Plasma MPO is elevated in CAD patients.
  • MPO may contribute to CAD by promoting LDL oxidation and reducing nitric oxide availability.
Abstract

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