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Glaucoma: Overview

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

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Related Experiment Video

Updated: Jun 1, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

Glaucoma.

Rajiv Shah¹, Richard P L Wormald

¹Department of Ophthalmology, St Vincent's Hospital, Sydney, Australia.

BMJ Clinical Evidence

|June 11, 2011

Summary

This systematic review evaluates treatments for glaucoma, including laser trabeculoplasty, medical treatments, and surgery. It assesses effectiveness and safety for various glaucoma types to guide clinical decisions.

Area of Science:

Ophthalmology
Clinical Medicine
Evidence-Based Practice

Background:

Glaucoma involves progressive optic nerve damage and visual field loss, impacting 1-2% of Caucasians over 40.
Elevated intraocular pressure is a key risk factor, but not universally present or predictive of damage.
Glaucoma exhibits higher prevalence and severity in Black populations.

Purpose of the Study:

To systematically review the effects of treatments for primary open-angle glaucoma and ocular hypertension.
To assess interventions for normal-tension glaucoma and acute angle-closure glaucoma.
To evaluate the effectiveness and safety of glaucoma treatment options.

Main Methods:

Systematic review of 12 studies including systematic reviews, RCTs, and observational studies.

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Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

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Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

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Last Updated: Jun 1, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

Searched major databases (Medline, Embase, Cochrane Library) up to May 2010.

Included safety alerts from regulatory agencies (FDA, MHRA) and applied GRADE evaluation.

Main Results:

Identified 12 relevant studies meeting inclusion criteria.
Evaluated evidence quality using the GRADE system.
Included information on laser trabeculoplasty, topical medical treatments, and surgical trabeculectomy.

Conclusions:

Presents information on the effectiveness and safety of key glaucoma interventions.
Highlights findings for laser trabeculoplasty, medical treatments, and trabeculectomy.
Provides evidence to inform treatment choices for various glaucoma conditions.