Related Experiment Video
Updated: Jun 1, 2026

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
Published on: September 26, 2022
Lactose intolerance in systemic nickel allergy syndrome
Systemic nickel allergy syndrome (SNAS) patients frequently experience lactose intolerance, with 74.7% testing positive. This suggests nickel may trigger digestive issues by causing inflammation in the gut.
Area of Science:
- Gastroenterology
- Allergology
- Immunology
Background:
- Systemic nickel allergy syndrome (SNAS) is characterized by cutaneous and digestive symptoms, linked to intestinal inflammation.
- The prevalence of lactose intolerance in SNAS patients has not been previously established.
Discussion:
- This study investigated lactose intolerance prevalence in SNAS patients versus healthy controls using lactose breath tests.
- A significantly higher prevalence of lactose intolerance was observed in SNAS patients (74.7%) compared to controls (6.6%).
Key Insights:
- Lactose intolerance is highly prevalent in patients with systemic nickel allergy syndrome.
- Nickel-induced intestinal inflammation may impair brush border enzymes, leading to hypolactasia in SNAS patients.
Outlook:
- Further research is needed to explore the impact of a nickel-low diet on lactase activity and gut health in SNAS.
- Investigating histological and immunological changes in response to dietary nickel reduction is warranted.
More Related Videos
04:34Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation
Published on: September 14, 2018
10:27Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
Related Concept Videos
Drug Toxicity: Allergic Reactions
Drug toxicity: Idiosyncratic Reactions
Allergic Drug Reactions
Allergic Reactions
Allergic Reactions: Anaphylaxis
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions