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Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
Published on: January 9, 2019
Follicular lymphoma grade 3B.
Itziar Salaverria1, Reiner Siebert
1Institute of Human Genetics, University Hospital Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Schwanenweg 24, D-24105 Kiel, Germany. isalaverria@medgen.uni-kiel.de
Best Practice & Research. Clinical Haematology
|June 11, 2011
Summary
Follicular lymphoma grade 3B (FL3B) is a distinct subtype often co-occurring with diffuse large B-cell lymphoma (DLBCL). FL3B exhibits unique genetic features, differing significantly from other follicular lymphoma grades.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Follicular lymphoma (FL) grade 3B (FL3B) is characterized by over 15% centroblasts in solid sheets.
- FL3B frequently coexists with diffuse large B-cell lymphoma (DLBCL).
Purpose of the Study:
- To review the current knowledge on the morphological, cytogenetic, and molecular characteristics of FL3B.
- To highlight the distinct features of FL3B compared to other FL subtypes and its resemblance to DLBCL.
Main Methods:
- Review of existing literature on FL3B.
- Analysis of morphological, cytogenetic, and molecular data from FL3B cases.
Main Results:
- FL3B often lacks CD10 expression (approx. 50%), has lower BCL2 positivity (69%), and increased TP53 expression (31%).
- The t(14;18) translocation is rare in FL3B (13%), while BCL6 locus translocations (3q27) are common (44%).
- FL3B shares many features with DLBCL, and a diffuse component is linked to poor prognosis, except in pediatric cases.
Conclusions:
- FL3B is a unique subtype of follicular lymphoma with distinct biological features.
- Understanding these features is crucial for accurate diagnosis and treatment strategies for FL3B and DLBCL.
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