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Follicular lymphoma grade 3B

Itziar Salaverria1, Reiner Siebert

  • 1Institute of Human Genetics, University Hospital Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Schwanenweg 24, D-24105 Kiel, Germany. isalaverria@medgen.uni-kiel.de

Best Practice & Research. Clinical Haematology
|June 11, 2011
PubMed

Insights

Follicular lymphoma grade 3B (FL3B) is a distinct subtype often co-occurring with diffuse large B-cell lymphoma (DLBCL). FL3B exhibits unique genetic features, differing significantly from other follicular lymphoma grades.

Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Follicular lymphoma (FL) grade 3B (FL3B) is characterized by over 15% centroblasts in solid sheets.
  • FL3B frequently coexists with diffuse large B-cell lymphoma (DLBCL).

Purpose of the Study:

  • To review the current knowledge on the morphological, cytogenetic, and molecular characteristics of FL3B.
  • To highlight the distinct features of FL3B compared to other FL subtypes and its resemblance to DLBCL.

Main Methods:

  • Review of existing literature on FL3B.
  • Analysis of morphological, cytogenetic, and molecular data from FL3B cases.

Main Results:

  • FL3B often lacks CD10 expression (approx. 50%), has lower BCL2 positivity (69%), and increased TP53 expression (31%).
  • The t(14;18) translocation is rare in FL3B (13%), while BCL6 locus translocations (3q27) are common (44%).
  • FL3B shares many features with DLBCL, and a diffuse component is linked to poor prognosis, except in pediatric cases.

Conclusions:

  • FL3B is a unique subtype of follicular lymphoma with distinct biological features.
  • Understanding these features is crucial for accurate diagnosis and treatment strategies for FL3B and DLBCL.

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