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Perspective of clinical research in follicular NHL: interaction between science and industry

Gregg Fine1, Sandra Horning

  • 1Genentech BioOncology, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA. fine.gregg@gene.com

Best Practice & Research. Clinical Haematology
|June 11, 2011
PubMed

Insights

Curative therapy for follicular lymphoma (FL) is still needed. New trial designs and surrogate endpoints, like imaging, can help overcome challenges in drug development for this indolent cancer.

Area of Science:

  • Hematology
  • Oncology
  • Clinical Trial Design

Background:

  • Follicular lymphoma (FL) treatment has advanced, yet a cure remains elusive.
  • Improved progression-free survival in FL presents logistical and financial challenges for clinical research.
  • Indolent nature of FL complicates drug development and clinical investigation.

Purpose of the Study:

  • To explore strategies for addressing unmet needs in follicular lymphoma treatment.
  • To identify solutions for logistical and financial challenges in FL clinical trials.
  • To investigate the potential of surrogate endpoints and novel trial designs.

Main Methods:

  • Review of current challenges in follicular lymphoma clinical investigation.
  • Exploration of surrogate endpoints, including imaging and sensitive markers.
  • Consideration of alternative clinical trial designs.

Main Results:

  • Curative therapy for follicular lymphoma is an ongoing unmet need.
  • Progression-free survival improvements introduce new complexities in research.
  • Surrogate endpoints and alternative trial designs offer potential solutions.

Conclusions:

  • Novel approaches are necessary to overcome research hurdles in follicular lymphoma.
  • Surrogate endpoints and innovative trial designs can facilitate drug development.
  • Addressing logistical and financial challenges is crucial for advancing FL treatment.

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