Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Obesity

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...

Gut-Brain Axis

Gut-Brain Axis

The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...

Organization of the Brain

Organization of the Brain

The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...

Drug Dosing: Obese Patients

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

ART in Europe, 2020: results generated from European registries by ESHRE†.

Human reproduction (Oxford, England)·2025

Same author

Cumulative live birth rates in a freeze-all or fresh transfer strategy after one ART cycle in ovulatory women.

Reproductive biomedicine online·2025

Same author

Survey on ART and IUI: legislation, regulation, funding, and registries in European countries-an update.

Human reproduction (Oxford, England)·2024

Same author

No major differences in perinatal and maternal outcomes between uninterrupted embryo culture in time-lapse system and conventional embryo culture.

Human reproduction (Oxford, England)·2023

Same author

Puberty disorders among ART-conceived singletons: a Nordic register study from the CoNARTaS group.

Human reproduction (Oxford, England)·2022

Same author

ART in Europe, 2018: results generated from European registries by ESHRE.

Human reproduction open·2022

Same journal

Calcitonin Gene-Related Peptide-Induced Central Sensitization: A Hypothesis for Long COVID Symptoms.

Medical hypotheses·2026

Same journal

Subclinical mastitis during lactation: a modifiable risk factor for breast cancer?

Medical hypotheses·2025

Same journal

The Role of Hemispheric Sensory Shifts: Impacts on Stretch Reflex and Motor Plasticity Post-Stroke.

Medical hypotheses·2025

Same journal

Neuron-Targeted Exosome Therapy: A Novel Approach for Treating Cardiogenic Dementia via RyR2 Inhibition.

Medical hypotheses·2025

Same journal

How the Somatosensory System Adapts to the Motor Change in Stroke: A Hemispheric Shift?

Medical hypotheses·2024

Same journal

Unstable Plaque is a Treatable Cause of Cognitive Decline.

Medical hypotheses·2024

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 1, 2026

Control of Eating Behavior Using a Novel Feedback System

Control of Eating Behavior Using a Novel Feedback System

Published on: May 8, 2018

Obesity and the brain.

P Södersten¹, C Bergh, M Zandian

¹Karolinska Institutet, Section of Applied Neuroendocrinology, NVS, Mando Group AB, Mandometer Clinic, Novum, S-141 04 Huddinge, Sweden. per.sodersten@ki.se

Medical Hypotheses

|June 11, 2011

Summary

This summary is machine-generated.

Obesity research focusing on the brain has yielded limited treatment success. External support, like real-time feedback, helps individuals manage eating behavior and improve health.

More Related Videos

Methods for Presenting Real-world Objects Under Controlled Laboratory Conditions

Methods for Presenting Real-world Objects Under Controlled Laboratory Conditions

Published on: June 21, 2019

Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography

Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography

Published on: April 4, 2012

Related Experiment Videos

Last Updated: Jun 1, 2026

Control of Eating Behavior Using a Novel Feedback System

Control of Eating Behavior Using a Novel Feedback System

Published on: May 8, 2018

Methods for Presenting Real-world Objects Under Controlled Laboratory Conditions

Methods for Presenting Real-world Objects Under Controlled Laboratory Conditions

Published on: June 21, 2019

Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography

Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography

Published on: April 4, 2012

Area of Science:

Behavioral neuroscience
Obesity research
Health psychology

Background:

Global obesity rates are rising, prompting extensive research into brain-based causes.
Current brain-centric approaches have shown minimal success in developing effective obesity treatments.
The hypothesis that the brain solely controls behavior may be an artifact of research tools.

Purpose of the Study:

To challenge the brain-centric hypothesis of eating behavior control.
To propose that the brain plays a permissive, not causal, role in eating.
To investigate the efficacy of external support for weight management.

Main Methods:

Two randomized controlled trials were conducted.
Intervention involved on-line, real-time computer feedback on eating behavior and fullness.
Participants received guidance on normal eating patterns and satiety cues.

Main Results:

External support via real-time feedback significantly improved eating behavior.
Both under- and overweight participants demonstrated enhanced ability to adjust eating habits.
The intervention led to measurable improvements in participants' health.

Conclusions:

Humans may require external support for weight management due to evolutionary factors favoring high food intake when energy expenditure is low.
The brain's role in eating behavior is permissive, not strictly causal.
Real-time feedback interventions are effective in helping individuals regulate eating and improve health outcomes.