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Related Concept Videos

Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

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Addition of autologous stem-cell transplantation to an ibrutinib-containing first-line treatment in patients aged 18-65 years with mantle cell lymphoma (TRIANGLE): 4·5-year follow-up of a three-arm, randomised, open-label, phase 3 superiority trial of the European MCL Network.

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Related Experiment Video

Updated: Jun 1, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Mantle cell lymphoma.

Sergio Cortelazzo1, Maurilio Ponzoni, Andrés J M Ferreri

  • 1Hematology and Bone Marrow Transplantation Unit, Azienda Ospedaliera Bolzano, Italy.

Critical Reviews in Oncology/Hematology
|June 11, 2011
PubMed
Summary
This summary is machine-generated.

Mantle cell lymphoma (MCL) management is evolving. While rituximab improves response rates, survival benefits are still under investigation, necessitating clinical trials for better treatment options.

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Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma
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Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma

Published on: September 12, 2025

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Last Updated: Jun 1, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma
08:31

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma

Published on: September 12, 2025

Area of Science:

  • Hematology
  • Oncology
  • Clinical Research

Background:

  • Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin lymphoma with a historically poor prognosis.
  • Recent advancements have marginally improved outcomes, but significant challenges remain in optimizing treatment strategies.

Purpose of the Study:

  • To review current treatment approaches for MCL, including conventional chemotherapy, rituximab, autologous stem cell transplant (ASCT), and emerging targeted therapies.
  • To identify areas requiring further investigation, such as optimal therapeutic timing, regimens, and the clinical significance of molecular remission.

Main Methods:

  • Review of recent research findings and clinical trial data concerning MCL treatment.
  • Analysis of the efficacy and limitations of various therapeutic modalities, including immunochemotherapy and stem cell transplantation.

Main Results:

  • Rituximab addition to chemotherapy improves response rates but not overall survival compared to chemotherapy alone.
  • Intensive frontline therapies with rituximab and ASCT improve progression-free survival, but overall survival impact is unproven.
  • Alternative, less intensive regimens exist for patients ineligible for intensive therapy.

Conclusions:

  • The optimal management of MCL is still evolving, with ongoing research into targeted therapies and treatment de-escalation.
  • Enrollment in clinical trials is crucial for identifying superior treatment strategies and improving patient outcomes in MCL.