Related Experiment Videos
[Hodgkin lymphoma in the elderly]
Tiphaine Belleville1, Samir Bouhadiba, Juliette Fontaine
1Hôpital Charles-Foix , Laboratoire d'hématologie, Ivry-sur-Seine.
Annales De Biologie Clinique
|June 11, 2011
Summary
This case study details Hodgkin's lymphoma in a 75-year-old man presenting with cardiopulmonary issues. Reed-Sternberg cells confirmed the diagnosis, but chemotherapy was withheld due to the patient's poor health.
Area of Science:
- Geriatric Medicine
- Hematology
- Oncology
Background:
- Hodgkin's lymphoma (HL) is a malignancy of the lymphatic system.
- Elderly patients present unique diagnostic and therapeutic challenges in HL.
- Acute cardiopulmonary insufficiency can be an atypical presentation of HL in older adults.
Observation:
- A 75-year-old male presented with acute cardiopulmonary insufficiency and enlarged lymph nodes.
- Diagnostic procedures included lymph node aspiration and bone marrow biopsy.
- Microscopic examination revealed Reed-Sternberg cells, indicative of Hodgkin's disease.
Findings:
- The patient was diagnosed with Hodgkin's lymphoma.
- Due to the patient's critical condition, chemotherapy was not administered.
- The case highlights the importance of considering HL in elderly patients with non-specific symptoms.
Implications:
- This case underscores the need for a thorough diagnostic workup in elderly patients with deteriorating health.
- It emphasizes the modified treatment strategies required for Hodgkin's lymphoma in the geriatric population.
- Understanding the specific features of HL in the elderly is crucial for appropriate management.
Related Concept Videos
Drug Dosing: Geriatric Patients
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Pharmacodynamics in Geriatric Patients: Effects of Age
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Secondary Lymphoid Organs
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Primary Lymphoid Organs
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...