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Updated: Jun 1, 2026
13:08
Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
[Factor V deficiency and pregnancy: a case report]
Mohamed Ayedi1, Kais Chaabene, Ines Jedidi
1Service d'anesthésie réanimation, Hôpital Hedi Chaker, Tunisie. drhamadiayedi@yahoo.fr
Annales De Biologie Clinique
|June 11, 2011
Summary
Factor V deficiency, a rare bleeding disorder, poses risks during childbirth. This case study shows fresh frozen plasma transfusions effectively prevented postpartum hemorrhage in a pregnant patient with factor V deficiency undergoing Cesarean delivery.
Area of Science:
- Hematology
- Obstetrics & Gynecology
- Genetics
Background:
- Factor V deficiency is an extremely rare inherited coagulation disorder.
- It is associated with a significant risk of bleeding, particularly during childbirth and the postpartum period.
Observation:
- A pregnant woman diagnosed with factor V deficiency underwent a Cesarean section delivery.
- Management involved a specific transfusion protocol to mitigate bleeding risks.
Findings:
- The patient received 20 mL/kg of fresh frozen plasma pre-surgery.
- Postpartum, she received 5 mL/kg of fresh frozen plasma every 12 hours for 7 days.
- This therapeutic approach successfully prevented hemorrhagic complications.
Implications:
- This case highlights the efficacy of fresh frozen plasma transfusion in managing factor V deficiency during pregnancy and delivery.
- It provides a potential management strategy for similar rare bleeding disorder cases in obstetrics.
- Ensuring adequate coagulation factor levels is crucial for safe delivery in patients with inherited bleeding disorders.
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