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Related Experiment Videos

Final ART success rates: a 10 years survey.

C Gnoth1, B Maxrath, T Skonieczny

  • 1Centre for Family Planning, Gynaecological Endocrinology and Reproductive Medicine, green-ivf, Department of Obstetrics and Gynaecology, University of Cologne, Rheydter Str 143, D-41515 Grevenbroich, Germany. dr.christian.gnoth@rmz-nrw.de

Human Reproduction (Oxford, England)
|June 11, 2011
PubMed
Summary

Cumulative live birth rates (CLBRs) indicate IVF success better than per-cycle rates. Continued treatment helps most couples achieve live births, reaching natural fertility rates.

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Area of Science:

  • Reproductive Medicine
  • In Vitro Fertilization (IVF)
  • Human Reproduction

Background:

  • Cumulative pregnancy rates (CPRs) and live birth rates (CLBRs) offer superior metrics for IVF program success compared to cross-sectional data.
  • These cumulative rates aid in estimating a patient's likelihood of conception and facilitate comparisons between fertility centers and treatment approaches.

Purpose of the Study:

  • To evaluate the cumulative live birth rates (CLBRs) in assisted reproductive technology (ART) over a 10-year period.
  • To compare the effectiveness of continued IVF treatment versus discontinuation.
  • To assess ART's ability to achieve natural fertility rates.

Main Methods:

  • A 10-year cohort study included patients undergoing their first assisted reproductive technique (ART) cycle.

Related Experiment Videos

  • Patients were followed until live birth or treatment cessation, including IVF, ICSI, and cryo-cycles.
  • Kaplan-Meier method estimated CPRs and CLBRs based on treatment cycles and embryo transfers, assuming similar success rates for those discontinuing treatment.

    • Main Results:

    • The study included 3011 women, with 2068 children born.
    • For 3394 observed patients (8048 cycles), CLBR reached 52% after 3 cycles, 72% after 6 cycles, and 85% after 12 cycles.
    • A CLBR of approximately 50% was observed for patients under 40 after six cumulative embryo transfers; the mean live birth rate per fresh cycle and subsequent cryo-cycle was 33%.

    Conclusions:

    • Sustained infertility treatment allows most couples to achieve successful outcomes, reaching natural fertility rates.
    • Assisted reproductive technology (ART) can achieve, but not surpass, natural fertility rates.
    • CLBRs achieved internationally comparable levels, even under specific regulatory frameworks like Germany's Embryo Protection Law.