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Updated: Jun 1, 2026
05:53
Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
Published on: July 6, 2013
Cytomegalovirus: pathogen, paradigm, and puzzle
Michael Boeckh1, Adam P Geballe
1Division of Vaccine and Infectious Disease, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
The Journal of Clinical Investigation
|June 11, 2011
Summary
Human cytomegalovirus (CMV) causes disease in immunocompromised individuals. Recent advances improve understanding and management of this herpesvirus, though persistence and pathogenesis mechanisms require further study.
Area of Science:
- Virology
- Immunology
- Infectious Diseases
Background:
- Human cytomegalovirus (CMV) is a common herpesvirus with significant health impacts, particularly in immunocompromised populations.
- CMV infection is a major concern for transplant recipients, individuals with advanced AIDS, and congenitally infected newborns.
Observation:
- Despite advances in diagnostics and treatment, key aspects of CMV remain poorly understood.
- Uncertainties persist regarding the mechanisms of viral persistence and pathogenesis.
Findings:
- Recent molecular virology and diagnostic improvements enhance the management of CMV infections.
- Research is actively exploring hypothesized roles of CMV in various human illnesses.
Implications:
- Continued research into CMV persistence and pathogenesis is crucial for developing novel therapeutic strategies.
- A deeper understanding of CMV will improve clinical outcomes for vulnerable patient groups.
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