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Relationship between uric acid and subtle cognitive dysfunction in chronic kidney disease.
Baris Afsar1, Rengin Elsurer, Adrian Covic
1Division of Nephrology, Department of Medicine, Zonguldak State Hospital, Zonguldak, Turkey.
American Journal of Nephrology
|June 11, 2011
Summary
Elevated serum uric acid is linked to cognitive decline in chronic kidney disease (CKD) patients. Higher uric acid levels correlate with worse cognitive test scores in this population.
Area of Science:
- Nephrology
- Neurology
- Biochemistry
Background:
- Elevated serum uric acid is linked to cognitive dysfunction in the elderly.
- Chronic kidney disease (CKD) often involves elevated uric acid, but its impact on cognition in CKD patients is unclear.
Purpose of the Study:
- To investigate the association between serum uric acid levels and cognitive function in patients with chronic kidney disease.
Main Methods:
- 247 CKD patients (eGFR <60/ml/min/1.73 m(2)) were assessed using the Standardized Mini-Mental State Examination (SMMSE).
- Exclusion criteria included dementia, depression, psychiatric disorders, uric acid-lowering therapy, severe anemia, or active cardiovascular/cerebrovascular disease.
Main Results:
- SMMSE scores showed a trend of deterioration with increasing quartiles of serum uric acid (p=0.019).
- Post-hoc analysis revealed significant differences between the lowest and highest uric acid groups (p=0.025).
- Multivariate regression identified age, education, cerebrovascular disease, and serum uric acid as independent predictors of SMMSE scores.
Conclusions:
- Serum uric acid levels are independently and inversely associated with mild cognitive dysfunction in CKD patients.
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