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Related Experiment Video

Updated: Jun 1, 2026

Establishing a Device for Sleep Deprivation in Mice

Establishing a Device for Sleep Deprivation in Mice

Published on: September 22, 2023

Sleep and obesity.

Guglielmo Beccuti¹, Silvana Pannain

¹Department of Medicine, University of Chicago, Chicago, IL 60637, USA.

Current Opinion in Clinical Nutrition and Metabolic Care

|June 11, 2011

Summary

This summary is machine-generated.

Short sleep duration and poor sleep quality are emerging risk factors for obesity in adults. This review highlights recent evidence linking insufficient sleep to metabolic and endocrine changes that promote weight gain.

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Area of Science:

Metabolic Health
Obesity Research
Sleep Science

Background:

The global prevalence of obesity has doubled since 1980, with 1 in 10 adults obese in 2008.
Obesity disproportionately affects women more than men.
A concurrent trend of reduced sleep duration and increased complaints of poor sleep quality has been observed worldwide.

Purpose of the Study:

To review the latest scientific evidence connecting reduced sleep duration and poor sleep quality with obesity in adult populations.
To synthesize findings from laboratory and epidemiological studies.

Main Methods:

Review of published and unpublished health examination surveys.
Analysis of epidemiological studies.
Examination of laboratory-based research.

Main Results:

Growing evidence indicates that short sleep duration and poor sleep quality are significant risk factors for obesity.
Sleep loss is associated with metabolic and endocrine alterations, including impaired glucose tolerance and insulin sensitivity.
Hormonal changes linked to sleep deprivation include increased ghrelin, decreased leptin, elevated cortisol, and increased appetite.

Conclusions:

Sleep plays a crucial role in regulating neuroendocrine function and glucose metabolism.
Sleep loss leads to detrimental metabolic and endocrine changes that contribute to obesity.
Recent evidence strongly supports the association between insufficient sleep and an increased risk of obesity.