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Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
Published on: November 1, 2017
Epigenetics of haematopoietic cell development.
Howard Cedar1, Yehudit Bergman
1Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hebrew University Medical School, P.O.B. 12272, Ein Kerem, Jerusalem, Israel, 91120.
Nature Reviews. Immunology
|June 11, 2011
Summary
This review explores epigenetic changes during immune cell development from haematopoietic stem cells. It details how chromatin accessibility controls gene expression and DNA recombination for cell specialization.
Area of Science:
- Immunology and developmental biology.
- Epigenetics and gene regulation.
Background:
- Immune cells develop from haematopoietic stem cells through a staged process.
- Cell potential is restricted, leading to specialized innate immune cells and lymphocytes.
Purpose of the Study:
- To review epigenetic modifications in immune cell differentiation.
- To elucidate the programming mechanisms controlling this process.
Main Methods:
- Review of existing literature on epigenetic regulation.
- Analysis of gene expression and DNA recombination control mechanisms.
Main Results:
- Epigenetic changes, particularly chromatin accessibility, are crucial for immune cell differentiation.
- These changes regulate gene expression and DNA recombination pathways.
Conclusions:
- Understanding epigenetic programming is key to deciphering immune cell development.
- Chromatin accessibility plays a central role in mediating cell fate decisions.
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