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Updated: Jun 1, 2026
06:15
Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay
Published on: September 7, 2018
Expanding TRAF function: TRAF3 as a tri-faced immune regulator.
Hans Häcker1, Ping-Hui Tseng, Michael Karin
1Department of Infectious Diseases, St. Jude Childrens Research Hospital, Memphis, Tennessee 38105, USA. hans.haecker@stjude.org
Nature Reviews. Immunology
|June 11, 2011
Summary
Tumour necrosis factor receptor (TNFR)-associated factor 3 (TRAF3) regulates key immune responses. This review details TRAF3
Area of Science:
- Immunology
- Molecular Biology
- Cell Signalling
Background:
- Tumour necrosis factor receptor (TNFR)-associated factor (TRAF) proteins are crucial mediators in signalling pathways.
- TRAFs are involved in diverse biological processes, including cytokine production and cell survival.
- The specific role of TRAF3 was previously unclear.
Purpose of the Study:
- To review the current understanding of TRAF3 function in TNFR and Toll-like receptor (TLR) signalling.
- To discuss the implications of TRAF3 in disease pathogenesis.
Main Methods:
- Literature review of studies on TRAF3 function.
- Analysis of TRAF3's role in TNFR and TLR signalling pathways.
- Examination of TRAF3's involvement in various disease contexts.
Main Results:
- TRAF3 acts as a versatile regulator in immune signalling.
- TRAF3 positively controls type I interferon production.
- TRAF3 negatively regulates mitogen-activated protein kinase (MAPK) activation and alternative nuclear factor-κB (NF-κB) signalling.
Conclusions:
- TRAF3 plays a critical, multifaceted role in TNFR and TLR signalling.
- Understanding TRAF3's function is key to comprehending immune responses and related diseases.
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