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Updated: Jun 1, 2026

Assessment of Child Anthropometry in a Large Epidemiologic Study
Published on: February 2, 2017
Evolution of obesity in a low birth weight cohort
P H Casey1, R H Bradley, L Whiteside-Mansell
1Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA. CaseyPatrickH@uams.edu
Insights
Obesity is common in low birth weight preterm infants, with rapid first-year weight gain predicting later obesity. This highlights the need for early monitoring and intervention strategies for this vulnerable population.
Area of Science:
- Pediatric Endocrinology
- Developmental Pediatrics
- Public Health Nutrition
Background:
- Low birth weight preterm (LBWPT) infants face increased risks for adverse health outcomes.
- Understanding the long-term trajectory of obesity in this population is crucial for developing targeted interventions.
Purpose of the Study:
- To examine the evolution of obesity status (OS) in LBWPT infants up to 8 years of age.
- To identify if rapid weight gain during the first year of life predicts OS at 8 years.
Main Methods:
- A longitudinal cohort of 985 LBWPT infants (birth weight ≤2500 g, gestation age ≤37 weeks) was followed.
- Infants were assessed at 3, 5, 6.5, and 8 years for weight, height, and body mass index (BMI).
- Logistic regression analyses identified predictors of 8-year OS, including first-year weight gain, maternal factors, and infant characteristics.
Main Results:
- Obesity prevalence increased from 2.3% at 3 years to 8.7% at 8 years.
- Infants born weighing ≤1500 g had the lowest OS prevalence.
- First-year weight gain (aOR=2.7), maternal Hispanic race (aOR=2.8), and maternal obesity (aOR=3.4) significantly predicted 8-year OS.
Conclusions:
- Obesity is a significant concern in LBWPT children throughout childhood.
- Early rapid weight gain in the first year is a key predictor of developing obesity by age 8.
- Birth weight category influences obesity prevalence, with lower birth weights showing lower rates.
Objective:
The objective of this study was to determine the evolution of obesity status (OS) in a longitudinal cohort of low birth weight preterm (LBWPT) infants to an age of 8 years, and to determine whether rapid weight gain in the first year of life independently predicts 8-year OS.
Study Design:
In total, 985 infants (birth weight ≤2500 g, gestation age ≤37 weeks) were recruited from the nursery in an eight-site intervention research program and were evaluated at an age of 3, 5, 6.5 and 8 years. Weight and height were measured by standard protocol at each visit and body mass index was calculated. Obesity status is ≥95% for age and sex. Multiple logistic analyses were performed on 8-year OS with predictor variables including infant race, gender, small for gestational age status, birth weight category, neonatal health index, treatment group and first-year weight gain; maternal education and weight status before conception; and HOME Inventory.
Result:
Overall, 2.3% were OS at an age of 3 years, 6.1% at an age of 5 years, 7.7% at age 6.5 years and 8.7% at an age 8 years. OS varied by birth weight category at each visit. The infants born ≤1500 g had the lowest prevalence of OS at each age. In the logistic regression, maternal race (Hispanic) (adjusted odds ratio=2.8, confidence interval=1.2 to 6.8), maternal obese status (adjusted odds ratio 3.4, confidence interval=1.5 to 7.8) and first-year weight gain (adjusted odds ratio=2.7, confidence interval=1.9 to 3.9), significantly predicted 8-year OS.
Conclusion:
OS is common in LBWPT infants during childhood, and prevalence varies by birth weight category. High weight gain in the first year of life is an important predictor of the development of OS in LBWPT children.
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