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Phenotyping Mouse Pulmonary Function In Vivo with the Lung Diffusing Capacity
07:13

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Published on: January 6, 2015

Genetic influences on pulmonary function: a large sample twin study.

Truls S Ingebrigtsen1, Simon F Thomsen, Sophie van der Sluis

  • 1Department of Respiratory Medicine, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400, Copenhagen, Denmark. trulsingebrigtsen@gmail.com

Lung
|June 11, 2011
PubMed
Summary
This summary is machine-generated.

Genetic factors significantly influence lung function measures like forced expiratory volume in one second (FEV1) and forced vital capacity (FVC). While qualitative sex differences in heritability are absent, quantitative differences exist for peak expiratory flow (PEF), notably in men.

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Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique
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Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique
13:10

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Published on: May 15, 2013

Area of Science:

  • Pulmonary Medicine
  • Genetics
  • Twin Studies

Background:

  • Heritability of spirometry measures like FEV1, FVC, and PEF is not well-established in large twin studies.
  • Understanding genetic contributions to lung function is crucial for respiratory health research.

Purpose of the Study:

  • To evaluate the genetic contribution to individual differences in FEV1, FVC, and PEF.
  • To assess potential sex differences in the heritability of these spirometric measures.

Main Methods:

  • Utilized data from a large population-based Danish twin study (4,314 individuals, aged 46-68).
  • Employed home-based spirometry with hand-held devices and evaluated flow-volume curves.
  • Applied modern variance component sex-limitation models, adjusting for age, height, and smoking.

Main Results:

  • Significant additive genetic effects observed for FEV1 (61%) and PEF in men (43%).
  • FVC showed both additive (26%) and dominant (29%) genetic contributions.
  • No significant qualitative genetic differences between sexes for any measure; quantitative sex differences noted for PEF heritability.

Conclusions:

  • Genetic factors play a significant role in individual variability of FEV1, FVC, and PEF.
  • Absence of qualitative sex differences suggests shared genetic underpinnings, but quantitative differences in PEF heritability highlight sex-specific genetic influences.