Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunologic abnormalities in chronic fatigue syndrome.

N G Klimas1, F R Salvato, R Morgan

  • 1Miami Veterans Administration Medical Center, Florida.

Journal of Clinical Microbiology
|June 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of Streptococcus pneumoniae in hospital-acquired pneumonia in adults.

The Journal of hospital infection·2020
Same author

Psychosocial and Neurohormonal Predictors of HIV Disease Progression (CD4 Cells and Viral Load): A 4 Year Prospective Study.

AIDS and behavior·2014
Same author

Pneumococcal empyema and complicated pneumonias: global trends in incidence, prevalence, and serotype epidemiology.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2014
Same author

Myalgic encephalomyelitis: International Consensus Criteria.

Journal of internal medicine·2011
Same author

Reduction in pediatric invasive pneumococcal disease in the Basque Country and Navarre, Spain, after introduction of the heptavalent pneumococcal conjugate vaccine.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2007
Same author

Burden of paediatric invasive pneumococcal disease in Europe, 2005.

Epidemiology and infection·2006

Chronic fatigue syndrome (CFS) patients exhibit significant immune system abnormalities, including reduced natural killer (NK) cell function and altered T and B cell populations. These immune dysfunctions suggest a potential link to chronic viral reactivation.

Area of Science:

  • Immunology
  • Virology
  • Cellular Biology

Background:

  • Chronic fatigue syndrome (CFS) presents complex clinical features with an uncertain cause.
  • Previous research suggests immune system dysfunction may play a role in CFS etiology.
  • Understanding cellular immune markers is crucial for characterizing CFS.

Purpose of the Study:

  • To comprehensively analyze laboratory markers of cellular immune function in patients with clinically defined CFS.
  • To identify specific immunological abnormalities associated with CFS.
  • To explore potential links between immune profiles and CFS pathogenesis.

Main Methods:

  • Studied 30 patients diagnosed with CFS.
  • Assessed natural killer (NK) cell cytotoxicity and cell counts (CD56).

Related Experiment Videos

  • Evaluated lymphoproliferative responses to mitogens (phytohemagglutinin, pokeweed), gamma interferon production, and lymphocyte phenotypic markers (CD8, CD4, CD20, CD21, etc.).

    • Main Results:

    • Patients with CFS showed significantly reduced NK cell cytotoxicity despite elevated NK cell numbers (CD56).
    • Decreased lymphoproliferative responses and gamma interferon production were observed.
    • Abnormalities in T cell subsets (increased CD8, decreased CD4+CD45RA+) and elevated B cell counts (CD20, CD21) were noted.
    • Immune marker patterns were consistent with chronic viral reactivation.

    Conclusions:

    • CFS is characterized by multiple cellular immune system abnormalities.
    • Reduced NK cell cytotoxicity and altered T and B cell profiles are key immunological findings in CFS.
    • The observed immune dysregulation patterns suggest a potential role for chronic viral reactivation in CFS pathogenesis.